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Many studies in humans have also provided evidence for a beneficial role of L supplementation, lowering the blood concentrations of inflammatory cytokines, while favoring the secretion of anti-inflammatory cytokines . Indeed, L reduced circulating complement factors [157,158], complement system activation , and factors potentially harmful to CV health . Other factors influencing atherosclerosis and CV risk, like lipid peroxidation and C-reactive protein serum concentrations, were shown to be reduced following L supplementation . Karppi et al. suggested that L plasma levels were inversely associated with circulating levels of oxidized LDL , whereas low circulating levels of L were associated with an increased risk of developing atrial fibrillation . In patients with early atherosclerosis, L supplementation (20 mg/d) for 3 months was associated with a significant reduction in plasma LDL-cholesterol and triglycerides . An RCT conducted on 144 patients with subclinical atherosclerosis demonstrated that L significantly decreased the carotid intima-media thickness , which is an established CV risk factor . In mononuclear cells of patients with stable angina or coronary acute syndrome, L negatively regulated the expression of inflammatory cytokines such as interleukin-1b, interleukin-6, and tumor necrosis factor-α . Interestingly, a recent study demonstrated an independent positive association between L plasma levels and telomere length , a suggested marker of the aging process and also proposed as a predictor of myocardial infarction .
Bone health is of great importance, especially in the elderly as decreased bone mineral density may lead to osteoporosis and fractures . In mice, L significantly stimulated bone formation and inhibited bone reabsorption through its regulatory activity on NF-κB . Similar results were obtained in vitro, where L was effective in increasing bone formation, preventing bone loss, and decreasing the interleukin-1-dependent differentiation of osteoclasts . Observational studies have confirmed the possible beneficial effects of L intake on total hip bone mineral density in men , supporting a positive role on bone health .
As with most medications, this product should be stored at room temperature. Store it in a secure location where it will not be exposed to excessive heat, moisture or direct sunlight. Keep it out of reach of young children. Make sure that any leftover portion is disposed of safely.
This document contains useful information for those taking this medication. It is not intended, in any way, to replace the advice of a trained health professional. For more information, consult the manufacturer's literature, where you will find additional information about uncommon side effects as well as contraindications associated with this product. 041b061a72